One Health Institute
Inflammatory Bowel Disease Species affected: felines, canines, humans, equines Human Terminology: Inflammatory Bowel Disease, Crohn’s Disease, Ulcerative colitis Description: Inflammatory bowel disease (IBD) involves chronic inflammation of the gastrointestinal (GI) tract. Typical IBD symptoms in humans include severe and chronic diarrhea, abdominal pain, rectal bleeding, fatigue, and weight loss. Symptoms vary due to severity and […]
Mitral Valve Disease
(myxomatous mitral valve disease, chronic mitral valve disease, degenerative mitral valve disease, mitral insufficiency) Species affected: Humans, Canines Brief Disease Description: Mitral valve disease (MVD) can be congenital (a defect in the valve the patient is born with) or acquired (valve conditions that develop with aging or due to infection) and includes both mitral valve […]
Diabetes Natural Animal Model
Description: Diabetes mellitus is a metabolic disorder that is increasing in prevalence in people, dogs, and cats. In each species, the disorder results from a defect in insulin secretion or reduced insulin sensitivity. Insulin is an anabolic hormone produced by pancreatic beta cells, and the most famous of its many functions is to allow glucose […]
Epilepsy Natural Animal Model
Description: Epilepsy is a chronic neurological condition characterized by unpredictable seizures, and it affects both humans and animals. Management of epilepsy is often challenging, especially with Dravet syndrome and Lennox-Gastaut syndrome, which both manifest as early-onset, treatment-resistant epilepsy in young children. Dravet syndrome is thought to affect about 1 in every 22,000-40,000 people (Connolly 2016), […]
Chronic Kidney Disease
Chronic kidney disease (CKD) is reported in 1-3% of cats with an estimated one-third of cats developing CKD in their lifetime. In the US, 15% of adults, 37 million people, have CKD. In both cases, the disease prevalence increases with age: an estimated 38% of people over 65 years old and approximately 30% to 80% […]
Ocular Squamous Cell Carcinoma Natural Animal Model
Description: Ocular squamous cell carcinoma (SCC) is a form of neoplasia (e.g. cancer) affecting the eye of both animals and humans. Ocular SCC is relatively rare in humans, affecting 1 in 1,000,000 people in regions outside of Africa. Incidence is highest in Africa, due to increased rates of HIV and exposure to UV light, both […]
